{"id":5805,"date":"2024-12-06T08:13:26","date_gmt":"2024-12-06T14:13:26","guid":{"rendered":"https:\/\/www.vanderbilt.edu\/csb\/?p=5805"},"modified":"2024-12-06T08:13:26","modified_gmt":"2024-12-06T14:13:26","slug":"csb-research-spotlight-mchaourab-lab-describing-conformational-landscapes-of-cell-membrane-transporters","status":"publish","type":"post","link":"https:\/\/www.vanderbilt.edu\/csb\/2024\/12\/06\/csb-research-spotlight-mchaourab-lab-describing-conformational-landscapes-of-cell-membrane-transporters\/","title":{"rendered":"CSB Research Spotlight: Mchaourab Lab &#8211; Describing\u00a0 conformational landscapes of cell membrane transporters"},"content":{"rendered":"<p><img data-attachment-id=\"5360\" data-permalink=\"https:\/\/www.vanderbilt.edu\/csb\/2024\/06\/14\/research-spotlight-fesik-lab\/csb-research-spotlight\/\" data-orig-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/06\/14085600\/CSB-Research-Spotlight.png\" data-orig-size=\"500,300\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"CSB Research Spotlight\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/06\/14085600\/CSB-Research-Spotlight-300x180.png\" data-large-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/06\/14085600\/CSB-Research-Spotlight.png\" loading=\"lazy\" class=\"alignleft wp-image-5360\" src=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/06\/14085600\/CSB-Research-Spotlight.png\" alt=\"\" width=\"250\" height=\"150\" srcset=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/06\/14085600\/CSB-Research-Spotlight.png 500w, https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/06\/14085600\/CSB-Research-Spotlight-300x180.png 300w\" sizes=\"(max-width: 250px) 100vw, 250px\" \/>PhD student Alexandra Schwartz and Professor <a href=\"https:\/\/www.vanderbilt.edu\/csb\/faculty-core\/hassane-mchaourab\/\">Hassane Mchaourab<\/a> (Molecular Physiology and Biophysics, Center for Applied Artificial Intelligence in Protein Dynamics) developed a methodological blueprint to describe the structure of cell membrane transporters.<\/p>\n<p><a href=\"https:\/\/medschool.vanderbilt.edu\/basic-sciences\/2024\/12\/02\/research-snapshot-spectroscopy-and-ai-method-provide-unique-window-into-protein-structure-and-mechanism-of-action\/\" target=\"_blank\" rel=\"noopener\">Read more<\/a> to learn how the Spectroscopy and AI method provide a unique window into protein structure and a mechanism of action.<\/p>\n<p><em>Morphing of MhsT models obtained from SPEACH_AF illustrating its conformational changes:<\/em><\/p>\n<div style=\"width: 750px;\" class=\"wp-video\"><!--[if lt IE 9]><script>document.createElement('video');<\/script><![endif]-->\n<video class=\"wp-video-shortcode\" id=\"video-5805-1\" width=\"750\" height=\"698\" autoplay=\"1\" preload=\"metadata\" controls=\"controls\"><source type=\"video\/mp4\" src=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/12\/05173551\/2024-PNAS-video.mp4?_=1\" \/><a href=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/12\/05173551\/2024-PNAS-video.mp4\">https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/12\/05173551\/2024-PNAS-video.mp4<\/a><\/video><\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>PhD student Alexandra Schwartz and Professor Hassane Mchaourab (Molecular Physiology and Biophysics, Center for Applied Artificial Intelligence in Protein Dynamics) developed a methodological blueprint to describe the structure of cell membrane transporters. Read more to learn how the Spectroscopy and AI method provide a unique window into protein structure and a mechanism of action. Morphing&#8230;<\/p>\n","protected":false},"author":1185,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"spay_email":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false,"jetpack_publicize_feature_enabled":true},"categories":[1],"tags":[],"acf":[],"jetpack_featured_media_url":"","jetpack_publicize_connections":[],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/5805"}],"collection":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/users\/1185"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/comments?post=5805"}],"version-history":[{"count":5,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/5805\/revisions"}],"predecessor-version":[{"id":5810,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/5805\/revisions\/5810"}],"wp:attachment":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/media?parent=5805"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/categories?post=5805"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/tags?post=5805"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}