  {"id":6196,"date":"2025-09-29T09:55:50","date_gmt":"2025-09-29T14:55:50","guid":{"rendered":"https:\/\/www.vanderbilt.edu\/csb\/?p=6196"},"modified":"2025-09-29T09:55:50","modified_gmt":"2025-09-29T14:55:50","slug":"csb-research-spotlight-wankowicz-lab-from-single-snapshots-to-shapeshifting-proteins","status":"publish","type":"post","link":"https:\/\/www.vanderbilt.edu\/csb\/2025\/09\/29\/csb-research-spotlight-wankowicz-lab-from-single-snapshots-to-shapeshifting-proteins\/","title":{"rendered":"CSB Research Spotlight: Wankowicz Lab &#8211; From single snapshots to shapeshifting proteins"},"content":{"rendered":"<p><img data-attachment-id=\"5360\" data-permalink=\"https:\/\/www.vanderbilt.edu\/csb\/2024\/06\/14\/research-spotlight-fesik-lab\/csb-research-spotlight\/\" data-orig-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/06\/14085600\/CSB-Research-Spotlight.png\" data-orig-size=\"500,300\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"CSB Research Spotlight\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/06\/14085600\/CSB-Research-Spotlight-300x180.png\" data-large-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/06\/14085600\/CSB-Research-Spotlight.png\" loading=\"lazy\" class=\"alignleft wp-image-5360 size-medium\" src=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/06\/14085600\/CSB-Research-Spotlight-300x180.png\" alt=\"\" width=\"300\" height=\"180\" srcset=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/06\/14085600\/CSB-Research-Spotlight-300x180.png 300w, https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/06\/14085600\/CSB-Research-Spotlight.png 500w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>A new collaborative project called <strong>diffUSE<\/strong> involving 91ºÚÁÏÍø, Cornell University and the University of California, San Francisco is advancing scientist&#8217;s understanding of protein motion.<\/p>\n<figure id=\"attachment_5385\" aria-describedby=\"caption-attachment-5385\" style=\"width: 180px\" class=\"wp-caption alignright\"><img data-attachment-id=\"5385\" data-permalink=\"https:\/\/www.vanderbilt.edu\/csb\/faculty-core\/stephanie-wankowicz\/wankowicz\/\" data-orig-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/07\/09135415\/Wankowicz.jpg\" data-orig-size=\"400,533\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;5.6&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;ILCE-6400&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;1683330482&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;56&quot;,&quot;iso&quot;:&quot;250&quot;,&quot;shutter_speed&quot;:&quot;0.00625&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;1&quot;}\" data-image-title=\"Wankowicz\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/07\/09135415\/Wankowicz-225x300.jpg\" data-large-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/07\/09135415\/Wankowicz.jpg\" loading=\"lazy\" class=\"wp-image-5385\" src=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/07\/09135415\/Wankowicz.jpg\" alt=\"\" width=\"180\" height=\"240\" srcset=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/07\/09135415\/Wankowicz.jpg 400w, https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/07\/09135415\/Wankowicz-225x300.jpg 225w, https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/07\/09135415\/Wankowicz-108x144.jpg 108w, https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/07\/09135415\/Wankowicz-142x190.jpg 142w\" sizes=\"(max-width: 180px) 100vw, 180px\" \/><figcaption id=\"caption-attachment-5385\" class=\"wp-caption-text\">Stephanie Wankowicz, PhD Molecular Physiology and Biophysics<\/figcaption><\/figure>\n<p>The <strong><a href=\"https:\/\/wankowiczlab.com\/\">Wankowicz lab<\/a><\/strong> is a primary contributor to the $5 million, three-year project led by the <a href=\"https:\/\/astera.org\" target=\"_blank\" rel=\"noopener\">Astera Institute<\/a>. The project uses diffuse scattering, an overlooked signal measured by X-ray crystallography, to determine how protein dynamics are characterized, leading to a new paradigm in dynamic structural biology.<\/p>\n<p><a href=\"https:\/\/medschool.vanderbilt.edu\/basic-sciences\/2025\/09\/25\/beyond-the-fold-from-single-snapshots-to-shapeshifting-proteins\/\" target=\"_blank\" rel=\"noopener\">Read more<\/a> about how <strong>Project diffUSE<\/strong> is moving from a single, static structure to a dynamic, shapeshifting protein.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new collaborative project called diffUSE involving 91ºÚÁÏÍø, Cornell University and the University of California, San Francisco is advancing scientist&#8217;s understanding of protein motion. The Wankowicz lab is a primary contributor to the $5 million, three-year project led by the Astera Institute. The project uses diffuse scattering, an overlooked signal measured by X-ray crystallography,&#8230;<\/p>\n","protected":false},"author":1185,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"spay_email":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false,"jetpack_publicize_feature_enabled":true},"categories":[1],"tags":[],"acf":[],"jetpack_featured_media_url":"","jetpack_publicize_connections":[],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/6196"}],"collection":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/users\/1185"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/comments?post=6196"}],"version-history":[{"count":8,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/6196\/revisions"}],"predecessor-version":[{"id":6204,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/6196\/revisions\/6204"}],"wp:attachment":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/media?parent=6196"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/categories?post=6196"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/tags?post=6196"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}