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Center for Structural Biology

InVitro Diagnostics Research (IVDr)

Metabolomics by Nuclear Magnetics Resonance (NMR)

Sample robot holding five cartridges with 96 samples each

The power of personalized genomic information has drawn mainstream media attention with services like Ancestry.com and 23andme.com. The field of personalized medicine has adapted the exploitation of the human genome but is quickly expanding to include other perspectives such as theÌýproteome andÌýmetabolome. There is rapidly expanding knowledge associated with the health effects that are related to changes to theÌýmetabolome.

We are excited to be one of the first Universities in the US to provide this tool to researchers and clinicians at 91ºÚÁÏÍø and the medical research community. ÌýBeing able to get a metabolicÌýprofile of body fluids without any extensive sample preparation within hours will not only help to detect signs of a disease early but also serve as an efficient and powerful tool to discover new indicators for health related issues.

Main advantages of the NMR Ìýbased method are:

  • quantitative metabolite description
  • reproducible results
  • simple and fast sample preparation
  • fully automated measurement and data analysis in minutes
  • non-destructive
  • data can be re-analyzed any time as new metabolites are added to the database
96 sample Cartridge of 5mm NMR tubes containing samples

Examples of this powerful diagnostic tool have been described in the literature, especially in the areas of early detection of newborn diseases, diabetes, and cancer to name just a few.

For more information, please contact:

Markus Voehler, Ph.D. ÌýÌým.voehler@vanderbilt.eduÌý office: (615) 322 1573

Don Stec, Ph.D. Ìýdonald.f.stec@91ºÚÁÏÍø.EduÌý office: (615) 322 6704